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Index > Protein center > Ggt1(Gene name) > Rat
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  • Ggt1 (Gene name),
  • Gamma-glutamyltranspeptidase 1 (Protein name ),  GGT1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Ggt1(Ggt);
    Protein name:
    Gamma-glutamyltranspeptidase 1(GGT 1);
    Alternative:
    3.4.19.13;Glutathione hydrolase 1);Gamma-glutamyltransferase 1;3.4.19.14;Leukotriene-C4 hydrolase);
    CD:
    CD224;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Heterodimer composed of the light and heavy chains. The active site is located in the light chain.
    Function:
    Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate.
    Subcellular Location:
    Membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    568
    Sequence:
    50:
    MKNRFLVLGL | VAVVLVFVII | GLCIWLPTTS | GKPDHVYSRA | AVATDAKRCS | 
    100:
    EIGRDMLQEG | GSVVDAAIAS | LLCMGLINAH | SMGIGGGLFF | TIYNSTTRKA | 
    150:
    EVINAREMAP | RLANTSMFNN | SKDSEEGGLS | VAVPGEIRGY | ELAHQRHGRL | 
    200:
    PWARLFQPSI | QLARHGFPVG | KGLARALDKK | RDIIEKTPAL | CEVFCRQGKV | 
    250:
    LQEGETVTMP | KLADTLQILA | QEGARAFYNG | SLTAQIVKDI | QEAGGIMTVE | 
    300:
    DLNNYRAEVI | EHPMSIGLGD | STLYVPSAPL | SGPVLILILN | ILKGYNFSPK | 
    350:
    SVATPEQKAL | TYHRIVEAFR | FAYAKRTMLG | DPKFVDVSQV | IRNMSSEFYA | 
    400:
    TQLRARITDE | TTHPTAYYEP | EFYLPDDGGT | AHLSVVSEDG | SAVAATSTIN | 
    450:
    LYFGSKVLSR | VSGILFNDEM | DDFSSPNFTN | QFGVAPSPAN | FIKPGKQPLS | 
    500:
    SMCPSIIVDK | DGKVRMVVGA | SGGTQITTSV | ALAIINSLWF | GYDVKRAVEE | 
    550:
    PRLHNQLLPN | TTTVEKNIDQ | VVTAGLKTRH | HHTEVTPDFI | AVVQAVVRTS | 
    568:
    GGWAAASDSR | KGGEPAGY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat GGT 1
    Cat.:
    E1375h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat GGT 1
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    E1375m
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    96T
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    ELISA Kit for Rat GGT 1
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    E1375r
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    96T
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    ELISA Kit for Rat GGT 1
    Cat.:
    E1375p
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat GGT 1
    Cat.:
    U1375r
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat GGT 1
    Cat.:
    U1375p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat GGT 1
    Cat.:
    U1375m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat GGT 1
    Cat.:
    U1375h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Rat GGT 1
    Cat.:
    P1375Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat GGT 1
    Cat.:
    P1375Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat GGT 1
    Cat.:
    P1375Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat GGT 1
    Monoclonal Antibody for Rat GGT 1
    Monoclonal Antibody for Rat GGT 1
    Monoclonal Antibody for Rat GGT 1
    Monoclonal Antibody for Rat GGT 1
    Protein for Rat GGT 1
    Protein for Rat GGT 1
    Protein for Rat GGT 1
    Protein for Rat GGT 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Rat liver gamma glutamyl transpeptidase mRNA differs in the 5' untranslated sequence from the corresponding kidney mRNA."
      Griffiths S.A. , Manson M.M.
      Cancer Lett.46:69-74(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    2. 2.
      "Molecular cloning and nucleotide sequence of rat kidney gamma-glutamyl transpeptidase cDNA."
      Laperche Y. , Bulle F. , Aissani T. , Chobert M.-N. , Aggerbeck M. , Hanoune J. , Guellaen G.
      Proc. Natl. Acad. Sci. U.S.A.83:937-941(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 31-43 AND 380-388
      tissue: Kidney.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;SEQUENCE REVISION TO 66-135
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    5. 5.
      "Studies on the structure of gamma-glutamyltranspeptidase. III. Evidence that the amino terminus of the heavy subunit is the membrane binding segment."
      Matsuda Y. , Tsuji A. , Katunuma N.
      J. Biochem.93:1427-1433(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-21
    6. 6.
      "Functional characterization of the rat gamma-glutamyl transpeptidase promoter that is expressed and regulated in the liver and hepatoma cells."
      Brouillet A. , Darbouy M. , Okamoto T. , Chobert M.-N. , Lahuna O. , Garlatti M. , Goodspeed D.C. , Laperche Y.
      J. Biol. Chem.269:14878-14884(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-18
      strain: Wistar.
      tissue: Liver.
    7. 7.
      "Organization of the 5' end of the rat gamma-glutamyl transpeptidase gene: structure of a promoter active in the kidney."
      Kurauchi O. , Lahuna O. , Darbouy M. , Aggerbeck M. , Chobert M.-N. , Laperche Y.
      Biochemistry30:1618-1623(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9
      tissue: Kidney.
    8. 8.
      "Characterization and sequence of a cDNA clone of gamma-glutamyltranspeptidase."
      Coloma J. , Pitot H.C.
      Nucleic Acids Res.14:1393-1403(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-568
      tissue: Kidney.
    9. 9.
      "The primary structure of human gamma-glutamyl transpeptidase."
      Sakamuro D. , Yamazoe M. , Matsuda Y. , Kangawa K. , Taniguchi N. , Matsuo H. , Yoshikawa H. , Ogasawara N.
      Gene73:1-9(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 64-136
    10. 10.
      "Renal gamma-glutamyl transpeptidases: structural and immunological studies."
      Tate S.S. , Khadse V. , Wellner D.
      Arch. Biochem. Biophys.262:397-408(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-47 AND 380-402
      tissue: Kidney.
    11. 11.
      "Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species."
      Chikhi N. , Holic N. , Guellaen G. , Laperche Y.
      Comp. Biochem. Physiol.122B:367-380(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE ORGANIZATION;ALTERNATIVE PROMOTER USAGE
    12. 12.
      "Subunit structure and isozymic forms of gamma-glutamyl transpeptidase."
      Tate S.S. , Meister A.
      Proc. Natl. Acad. Sci. U.S.A.73:2599-2603(1976) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;SIALIC ACID CONTENT
    13. 13.
      "In vitro translation and processing of rat kidney gamma-glutamyl transpeptidase."
      Nash B. , Tate S.S.
      J. Biol. Chem.259:678-685(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION
    14. 14.
      "O-linked glycosylation of rat renal gamma-glutamyltranspeptidase adjacent to its membrane anchor domain."
      Blochberger T.C. , Sabatine J.M. , Lee Y.C. , Hughey R.P.
      J. Biol. Chem.264:20718-20722(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION
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